Vista can be a huge problem for LSP. There are many requests for LSP help involving Vista that it has even been awarded its very own category – Vista LSP Issues. You will see this on message boards spanning the web.
It seems that a large quantity of these problems come from two little mistakes. Some people install just the 32 bit DLLs and the 32 bit LSP or some will only install the 64 bit DLLs/LSP. When you are running a 32 bit application on a 64 bit operating system, then you need to have the 32 bit versions of the DLLs and the LSP. Also, when you are running 64 bit applications, you need the 64 bit versions as well.
Now I do realize that this is a huge over-simplification of the Vista and LSP problem, but it does come up so frequently that it deserves repeating. I know that there are other problems involving LSP Vista also. And those will need a lot more troubleshooting than this post will accomplish.
Houdini